Pulse Pressure, Endothelium Function, and Arterial Stiffness in Spontaneously Hypertensive Rats
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چکیده
منابع مشابه
Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats.
In rats, removal of the carotid arterial or abdominal aortic endothelium results in an acute increase of diameter and compliance. In humans, acute local administration of a specific NO synthase inhibitor increases radial artery compliance but not the diameter. The purpose of this review is to determine whether in spontaneously hypertensive rats (SHR), a cause-and-effect relationship may be obse...
متن کاملAortic stiffness and pulse pressure amplification in Wistar-Kyoto and spontaneously hypertensive rats.
In humans, increased body weight and arterial stiffness are significantly associated, independently of blood pressure (BP) level. The finding was never investigated in rodents devoid of metabolic disorders as spontaneously hypertensive rats (SHR). Using simultaneous catheterization of proximal and distal aorta, we measured body weight, intra-arterial BP, heart rate and their variability (spectr...
متن کاملArterial pressure and exaggerated natriuresis in spontaneously hypertensive rats.
We tested the hypothesis that the exaggerated natriuretJc response of spontaneously hypertensive rats (SHR) to intragastric volume expansion may be independent of the sustained level of arterial pressure. The SHRs were treated for 10 days with guanethldine S04, 25 mg/llter, and hydralazine HO, 80 mg/liter, in drinking water. Mean arterial pressure (MAP) in conscious treated SHRs (T-SHR) was 130...
متن کاملPulse pressure and arterial stiffness in rats: comparison with humans.
THE DEVELOPMENT of appropriate animal models for investigating human hypertension has been extremely valuable for studies of the natural history and the pathophysiological mechanisms of the disease (21). It has been considered that there is a strong similarity between spontaneously hypertensive rats (SHR) and patients with essential hypertension. Both have their apparent onsets of the condition...
متن کاملArterial stiffness, pulse pressure, and the kidney.
Classical studies indicate that the contribution of kidneys to hypertension is almost exclusively related to the association between mean arterial pressure (MAP) and vascular resistance. Recent reports including estimates of glomerular filtration rate (GFR) have shown that pulse pressure (PP) and pulse wave velocity, 2 major indices of arterial stiffness, now emerge as significant predictors of...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2001
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hy1201.096538